HPLC 2018 Washington

We gave a lecture and presented three posters at the 47th International Symposium on High Performance Liquid Phase Separations and Related Techniques in Washington D.C. 2018.

 

 

 

 

Lecture:
“On the Issue of Separating Diastereomers of Phosphorothioated
Oligonucleotides.”
Torgny Fornstedt(1), Martin Enmark(1), Jörgen Samuelsson(1), Maria Rova(1), Eivor Örnskov(2), Anders Karlsson(2)

1. Karlstad University, Karlstad, SWEDEN;

2. AstraZeneca, Molndal, SWEDEN
Poster:
“Highlighting often Neglected Experimental Parameters in Analytical Supercritical
Fluid Chromatography.”
Prof. Torgny Fornstedt(1) , Martin Enmark(1) ,  Jörgen Samuelsson(1), Anders Karsslon(2)

1. Karlstad University, Karlstad, SWEDEN;

2. AstraZeneca, Molndal, SWEDEN 
Poster:
“Why Gradient Elution Lead to Increased Robustness of SFC Separations.
Prof. Torgny Fornstedt(1), Martin Enmark(1) , Emelie Glenne(1) , Marek Lesko(1,2) , Annika Weinmann(3) , Tomas Leek(3) , Krzysztof Kaczmarski(2) , Magnus Klarqvist(3) , Jörgen Samuelsson(1)

1. Karlstad University, Karlstad, SWEDEN;
2. Rzeszow University of Technology, Rzeszow, POLAND;
3. AstraZeneca, Molndal, SWEDEN
 Poster:
“Diastereomer Separation of Phosphorothioated Oligonucleotides.
Prof. Torgny Fornstedt(1), Martin Enmark(1) , Jörgen Samuelsson(1), Maria Rova(1), Eivor Örnskov(2), Anders Karlsson(2)

1. Karlstad University, Karlstad, SWEDEN;

2. AstraZeneca, Molndal, SWEDEN

For more information please visit the symposium webpage:

http://www.hplc2018.org/

PREP 2018 Baltimore

We gave a keynote lecture and presented three posters at the 31st International Symposium on Preparative and Process Chromatography in Baltimore 2018.

 

 

 

 

Lecture:
“Increasing the Robustness of SFC: Examples from Chiral and Peptide Separations”
Prof. Torgny Fornstedt(1) , Martin Enmark(1) , Emelie Glenne(1) , Marek Lesko(1,2) , Annika Weinmann(3) , Tomas Leek(3) , Krzysztof Kaczmarski(2) , Magnus Klarqvist(3) , Jörgen Samuelsson(1)

1. Karlstad University, Karlstad, SWEDEN;
2. Rzeszow University of Technology, Rzeszow, POLAND;
3. AstraZeneca, Molndal, SWEDEN 
Poster:
“Proper Operational Conditions in Supercritical Fluid Chromatography of Complex Molecules, Set vs. Real Conditions”
Prof. Torgny Fornstedt(1) , Martin Enmark(1) ,  Jörgen Samuelsson(1), Anders Karsslon(2)

1. Karlstad University, Karlstad, SWEDEN;

2. AstraZeneca, Molndal, SWEDEN 
Poster:
Robust Operation of SFC using Peptide and Chiral Model Systems.”
Prof. Torgny Fornstedt(1) , Martin Enmark(1) , Emelie Glenne(1) , Marek Lesko(1,2) , Annika Weinmann(3) , Tomas Leek(3) , Krzysztof Kaczmarski(2) , Magnus Klarqvist(3) , Jörgen Samuelsson(1)

1. Karlstad University, Karlstad, SWEDEN;
2. Rzeszow University of Technology, Rzeszow, POLAND;
3. AstraZeneca, Molndal, SWEDEN
 Poster:
Separation of Phosphorothioated Oligonucleotides and their Diastereomers”
Prof. Torgny Fornstedt(1) , Martin Enmark(1) , Jörgen Samuelsson(1), Maria Rova(1), Eivor Örnskov(2), Anders Karlsson(2)

1. Karlstad University, Karlstad, SWEDEN;

2. AstraZeneca, Molndal, SWEDEN

For more information please visit the symposium webpage:

http://prepsymposium.org/index.html

Kick-Off Meeting for the KK-Synergy Project “Quality Control and Purification for New Biological Drugs”

Kick-Off Meeting for the KK-Synergy Project “Quality Control and Purification for New Biological Drugs”

On the 30th of November 2017 our research group, together with researchers from several companies and universities, had a most successful kick-off day at Karlstad University for our new KK-Synergy project. The aim of this project is to develop state-of-the-art quality control methods for biological pharmaceuticals, i.e., proteins or similar molecules, which mimics molecules in the body and are injected in the body to stimulate the immune system.

The project has a budget of approximately €2 million and four companies and three academic institutions participate: Attana AB, AstraZeneca, Akzo Nobel Pulp and Performance Chemicals AB, Ridgeview Instruments AB, Karlstad University, Linné University and Örebro University.

The picture below shows the kick-off day participants.

KK-kickoff-Kemivärlden-2017

An article (in Swedish) about the project can be found in ”Kemivärlden Biotech med Kemisk Tidskrift” number 8, December 2017 on page 8 (see link)

For additional information see also:

http://news.cision.com/attana/r/quality-control-of-biological-pharmaceuticals,c2411154

Kemivärlden nr 3 2017 p15-17

Thesis “Fundamental Investigations of Supercritical Fluid Chromatography”

On the 16th of october 2015 Martin Enmark defended his thesis on Supercritical Fluid Chromatography titled “Fundamental Investigations of Supercritical Fluid Chromatography”

The thesis can be downloaded via the Swedish University Library here:

Thesis download

The thesis was selected as thesis of the month by the Swedish magazine Kemivärlden Biotech med Kemisk Tidskrift. The excerpt can be downloaded here:

http://www.fssg.se/wp-content/uploads/2016/03/KV_7_2015_ebook_p42.pdf

The including papers Paper I – V can be downloaded here

Paper I: Determination of adsorption isotherms in supercritical fluid chromatography

Paper II: Investigations of plateau methods for adsorption isotherm determination in supercritical fluid chromatography

Paper III: Evaluation of co-solvent fraction, pressure and temperature effects in analytical and preparative supercritical fluid chromatography

Paper IV: A closer study of peak distortions in supercritical fluid chromatography

Paper V: Evaluation of scale-up from analytical to preparative supercritical fluid chromatography

For questions regarding the thesis please contact Torgny Fornstedt

Keynote lecture at ITP/NoSSS 2015

We gave at keynote lecture at the ITP/NoSSS 2015 symposium in Helsinki.

Prof. Torgny Fornstedt
Karlstad University, Department of Engineering and Chemical Sciences, Karlstad, Sweden
“Deeper Scientific Understanding of Regulatory Approved Analytical Methods with the Quality by Design Approach”

For more information please visit the symposium webpage:

http://www.helsinki.fi/itp2015/index.html

Lecture at HPLC 2015 Geneva

We attended the 42nd International Symposium on High Performance Liquid Phase Separation and Related Techniques in Geneva 2015 where we gave the following presentations:

Visualization and explaining serious deformations in Supercritical Fluid Chromatography due to the very injection principle Torgny Fornstedt(1), Martin Enmark(2) , Jörgen Samuelsson(2) , Dennis Åsberg(2) , Andrew Shalliker(3) (1) Karlstad University, (2) Department of Engineering and Chemical Sciences, INTERACT, Karlstad University, (3) Australian Centre for Research on Separation Science, School of Science and Health, University of Western Sydney, Parramatta, NSW, Australia

Deeper Scientific Understanding and Continuous Improvement of Regulatory Approved Analytical Methods Jörgen Samuelsson(1) , Dennis Åsberg(1) , Anders Karlsson(2) , Torgny Fornstedt(1) (1) Karlstad University, (2) Astra Zeneca

For more information please visit the symposium webpage:

http://www.hplc2015-geneva.org/